![]() The direct benefit of developing a self-disinfecting, low cost alginate impression material will be to the dental team (eg dentists, orthodontists, dental laboratory staff), who are at risk of infection due to cross-infection during the processing of dental impressions, as well as the public (patients). Beneficiaries in the academic sector are described in the section addressing 'Relevance to Academic Beneficiaries'. The proposed research will directly benefit elements from commercial, private and public sectors as well as indirectly benefiting policy makers and government agencies. To model the transit time from patient to laboratory, the killing rates for the alginates will be investigated. Tests will be performed under conditions simulating the oral cavity, by using artificial saliva and sterile human saliva, and disinfection of contaminants, both on the surface and within the impression material will be examined. Viruses, bacteria and the fungus Candida albicans (the cause of oral infections such as denture stomatitis and thrush) will be used to test the antimicrobial acivity of the formulations. Disinfection will be tested on impression materials contaminated with infectious agents from i) the respiratory tract and, due to global concerns of the risk posed by Mycobacterium tuberculosis (TB), a model organism for TB (Mycobacterium smegmatis) will also be included, ii) the oral cavity, iii) tap water, iv) the environment and v) skin. The formulations will be modified for the maintainance of a low pH together with the release of nitric oxide, a broad spectrum antimicrobial agent. This development will contribute significantly to reducing cross-contamination incidence and risk of infection due to the dental impression handling process from initial taking to final production of the denture.Three formulations will be developed building on earlier work with low pH alginates having anti-viral activity against the Herpes simplex virus. Hence, in this study novel self-disinfecting dental alginate formulations are being developed which are effective against a broad spectrum of microbes in order to address the globally recognised need for improved infection control.The main objective of the project is to develop an impression material that is self-disinfecting, non-toxic to the patient and that crucially, is low cost, thereby encouraging its use worldwide. ![]() There is a risk of microbial cross-infection via the impression material between the patient and dental staff due to microorganisms from the patient's mouth as well as from skin, the impression powder, water contaminants and the environment. However, various studies have reported that post-setting disinfection procedures are often not followed, and can compromise the dimensional stability of alginates. Currently, all dental impression materials are supposed to be disinfected as soon as they are removed from the patient's mouth, in order to minimise the risk of transmitting infectious agents to dental personnel. They are the major material used in developing countries, due to their low cost and ease of application. Globally alginates are one of the most frequently used elastic impression materials for taking dental impressions. The paste sets to a gel after some minutes. The dentist mixes a measured amount of the powder with water, to give a paste, which is placed in a tray and applied to the mouth. Alginates are supplied to the dentist in a powder form containing other ingredients, including setting agents. After some minutes, the material sets to an elastic rubber-like gel, whereupon the impression is removed from the mouth, and sent to the dental laboratory where a model is cast. ![]() Elastic impression materials are an important class of impression materials these are applied by the dentist to the patient's mouth as a dough or paste, and accurately reproduce the fine detail of the oral structures. An important part of restorative dentistry is taking an impression of the patient's mouth (teeth, gums and palate), in order to obtain a model to be used to construct dentures (partial or full), crowns or bridges. ![]()
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