![]() ![]() Patients using intravaginal miconazole products are advised not to rely on contraceptives to prevent pregnancy and sexually transmitted infections, as well as not to use tampons concurrently. As miconazole is typically applied topically and is minimally absorbed into the systemic circulation following application, the majority of patient reactions are limited to hypersensitivity and cases of anaphylaxis. Triple Paste Af is an azole antifungal that functions primarily through inhibition of a specific demethylase within the CYP450 complex. About 50% of an oral dose may be excreted unchanged in the faeces. Triple Paste Af is inactivated in the body and 10-20% of an oral dose is excreted in the urine, mainly as metabolites, within 6 days. When administered orally, Triple Paste Af is incompletely absorbed from the gastrointestinal tract, peak plasma levels of about 1 µg per ml have been achieved after a dose of 1 gm per day. It may act by interfering with the permeability of the fungal cell membranes. The active ingredient, Triple Paste Af, is a synthetic imidazole anti-fungal agent with a broad spectrum of activity against pathogenic fungi (including yeast and dermatophytes) and gram-positive bacteria (Staphylococcus and Streptococcus spp). Triple Paste Af topical cream does not stain skin or clothes. Triple Paste Af topical cream proved to be markedly effective in secondary infected mycoses, which under other treatments were resistant or reappeared. Triple Paste Af topical cream is a broad-spectrum antimycotic which offers a high antifungal activity against dermatophytes, yeasts and other phyco-Asco and Adelomycetes, with a potent antibacterial activity against Gram-positive bacilli and cocci. ![]()
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